PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer

Authors: Jennifer J Knox, Grainne O'Kane, Daniel King, Daniel Laheru, Amber N Habowski, Kenneth Yu, Kimberly Perez, Andrew J Aguirre, Zachary Coyne, Harry Harvey, Ronan A McLaughlin, Raymond W Jang, Robert C Grant, Elena C Elimova, Daniel J Renouf, Sandra Fischer, Kai Duan, Stephanie Ramotar, Gun Ho Jang, Amy Zhang, Craig E Devoe, Harshabad Singh, Michael J Pishvaian, Fieke E M Froeling, Muhammad W Saif, Eileen M O'Reilly, Erica S Tsang, Brian M Wolpin, Julie M Wilson, Anna Dodd, Trevor J Pugh, Xiang Y Ye, Steven Gallinger, David A Tuveson, Faiyaz Notta, Elizabeth M Jaffee

Reference: Journal of Clinical Oncology

DOI: 10.1200/JCO-25-00436

Year: 2025

Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial

Authors: Jennifer J Knox, Gun Ho Jang, Robert C Grant, Amy Zhang, Lucy Ma, Elena Elimova, Raymond Jang, Malcolm Moore, James Biagi, Mustapha Tehfe, Ravi Ramjeesingh, Erica S Tsang, Spring Holter, Stephanie Ramotar, Shawn Hutchinson, Sheng-Ben Liang, Ilinca M Lungu, Shari Moura, Yifan Wang, Sheron Perera, Michelle Chan-Seng-Yue, Maryam Monajemzadeh, Kyaw Aung, Rebecca Prince, Joan Miguel Romero, Jesus Fuentes-Antras, Galileo A Gonzalez Conchas, Sarah Picardo, Ricardo Gonzalez, Sangeet Ghai, Korosh Khalili, Tae Kyoung Kim, Karen Ng, John Bartlett, Trevor J Pugh, Sangeetha N Kalimuthu, Sandra E Fischer, Julie M Wilson, Anna Dodd, George Zogopoulos, Barbara T Grünwald, Faiyaz Notta, Steven Gallinger, Grainne M O'Kane.

Reference: Nature Communications

DOI: 10.1038/s41467-025-60808-z

Year: 2025

Cryptic genomic lesions in adverse-risk acute myeloid leukemia identified by integrated whole genome and transcriptome sequencing

Authors: Jaeseung C. Kim, Philip C. Zuzarte, Tracy Murphy, Michelle Chan-Seng-Yue, Andrew M. K. Brown, Paul M. Krzyzanowski, Adam C. Smith, Faiyaz Notta, Mark D. Minden & John D. McPherson.

Reference: Leukemia - Nature

DOI: 10.1038/s41375-019-0546-1

Year: 2020

A genetic roadmap of pancreatic cancer: still evolving

Authors: Faiyaz Notta, Stephan A Hahn, Francisco X Real.

Reference: Gut

DOI: 10.1136/gutjnl-2016-313317

Year: 2019

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

Authors: Faiyaz Notta, Michelle Chan-Seng-Yue, Mathieu Lemire, Yilong Li, Gavin W. Wilson, Ashton A. Connor, Robert E. Denroche, Sheng-Ben Liang, Andrew M. K. Brown, Jaeseung C. Kim, Tao Wang, Jared T. Simpson, Timothy Beck, Ayelet Borgida, Nicholas Buchner, Dianne Chadwick, Sara Hafezi-Bakhtiari, John E. Dick, Lawrence Heisler, Michael A. Hollingsworth, Emin Ibrahimov, Gun Ho Jang, Jeremy Johns, Lars G. T. Jorgensen, Calvin Law, Olga Ludkovski, Ilinca Lungu, Karen Ng, Danielle Pasternack, Gloria M. Petersen, Liran I. Shlush, Lee Timms, Ming-Sound Tsao, Julie M. Wilson, Christina K. Yung, George Zogopoulos, John M. S. Bartlett, Ludmil B. Alexandrov, Francisco X. Real, Sean P. Cleary, Michael H. Roehrl, John D. McPherson, Lincoln D. Stein, Thomas J. Hudson, Peter J. Campbell & Steven Gallinger.

Reference: Nature

DOI: 10.1038/nature19823

Year: 2016

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

Authors: Faiyaz Notta, Sasan Zandi, Naoya Takayama, Stephanie Dobson, Olga I. Gan, Gavin Wilson, Kerstin B. Kaufmann, Jessica McLeod, Elisa Laurenti, Cyrille F. Dunant, John D. McPherson, Lincoln D. Stein, Yigal Dror, & John E. Dick.

Reference: Science

DOI: 10.1126/science.aab2116

Year: 2015

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

Authors: Faiyaz Notta, Charles G. Mullighan, Jean C. Y. Wang, Armando Poeppl, Sergei Doulatov, Letha A. Phillips, Jing Ma, Mark D. Minden, James R. Downing & John E. Dick.

Reference: Nature

DOI:10.1038/nature09733

Year: 2011