PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer
Authors: Jennifer J Knox, Grainne O'Kane, Daniel King, Daniel Laheru, Amber N Habowski, Kenneth Yu, Kimberly Perez, Andrew J Aguirre, Zachary Coyne, Harry Harvey, Ronan A McLaughlin, Raymond W Jang, Robert C Grant, Elena C Elimova, Daniel J Renouf, Sandra Fischer, Kai Duan, Stephanie Ramotar, Gun Ho Jang, Amy Zhang, Craig E Devoe, Harshabad Singh, Michael J Pishvaian, Fieke E M Froeling, Muhammad W Saif, Eileen M O'Reilly, Erica S Tsang, Brian M Wolpin, Julie M Wilson, Anna Dodd, Trevor J Pugh, Xiang Y Ye, Steven Gallinger, David A Tuveson, Faiyaz Notta, Elizabeth M Jaffee.
Reference: Journal of Clinical Oncology
DOI: 10.1200/JCO-25-00436
Year: 2025
Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial
Authors: Jennifer J Knox, Gun Ho Jang, Robert C Grant, Amy Zhang, Lucy Ma, Elena Elimova, Raymond Jang, Malcolm Moore, James Biagi, Mustapha Tehfe, Ravi Ramjeesingh, Erica S Tsang, Spring Holter, Stephanie Ramotar, Shawn Hutchinson, Sheng-Ben Liang, Ilinca M Lungu, Shari Moura, Yifan Wang, Sheron Perera, Michelle Chan-Seng-Yue, Maryam Monajemzadeh, Kyaw Aung, Rebecca Prince, Joan Miguel Romero, Jesus Fuentes-Antras, Galileo A Gonzalez Conchas, Sarah Picardo, Ricardo Gonzalez, Sangeet Ghai, Korosh Khalili, Tae Kyoung Kim, Karen Ng, John Bartlett, Trevor J Pugh, Sangeetha N Kalimuthu, Sandra E Fischer, Julie M Wilson, Anna Dodd, George Zogopoulos, Barbara T Grünwald, Faiyaz Notta, Steven Gallinger, Grainne M O'Kane.
Reference: Nature Communications
DOI: 10.1038/s41467-025-60808-z
Year: 2025
The tandem duplicator phenotype may be a novel targetable subgroup in pancreatic cancer
Authors: Abdul R Farooq, Amy X Zhang, Michelle Chan-Seng-Yue, James T Topham, Grainne M O'Kane, Gun Ho Jang, Sandra Fischer, Anna Dodd, Spring Holter, Julie Wilson, Robert C Grant, Kyaw Lwin Aung, George Zogopoulos, Elena Elimova, Rebecca Prince, Raymond Jang, Malcolm Moore, James Biagi, Patricia Tang, Rachel Goodwin, Oliver F Bathe, Marco Marra, Janessa Laskin, Daniel J Renouf, David F Schaeffer, Joanna M Karasinska, Faiyaz Notta, Steven Gallinger, Jennifer J Knox, Erica S Tsang.
Reference: NPJ Precision Oncology
DOI:10.1038/s41698-025-00888-8
Year: 2025
Molecular Tumour Board-Guided Targeted Treatments for Biliary Tract Cancers in a Publicly Funded Healthcare System
Authors: Felix E G Beaudry, Zhihao Li, Ayelet Borgida, Anudari Zorigtbaatar Xin Wang, Maggie Hildebrand, Oumaima Hamza, Gun Ho Jang, Roxana Bucur, Anna Dodd, Julie Wilson, Rebecca C Auer, Samuel Saibil, Erica S Tsang, Arndt Vogel, Grainne M O'Kane, Steven Gallinger, Jennifer J Knox, Faiyaz Notta, Gonzalo Sapisochin, Robert C Grant.
Reference: Current Oncology
DOI: 10.3390/curroncol32020080
Year: 2025
GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer
Authors: Grainne M. O’Kane, Barbara T. Grünwald, Gun-Ho Jang, Mehdi Masoomian, Sarah Picardo, Robert C. Grant, Robert E. Denroche, Amy Zhang, Yifan Wang, Jessica K. Miller, Bernard Lam, Paul M. Krzyzanowski, Ilinca M. Lungu, John M.S. Bartlett, Melanie Peralta, Foram Vyas, Rama Khokha, James Biagi, Dianne Chadwick, Stephanie Ramotar, Shawn Hutchinson, Anna Dodd, Julie M. Wilson, Faiyaz Notta, George Zogopoulos, Steven Gallinger, Jennifer J. Knox, Sandra E. Fischer.
Reference: Clinical Cancer Research
DOI: 10.1158/1078-0432.CCR-19-3724
Year: 2020
Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome
Authors: Sangeetha N Kalimuthu, Gavin W Wilson, Robert C Grant, Matthew Seto, Grainne O’Kane, Rajkumar Vajpeyi, Faiyaz Notta, Steven Gallinger, Runjan Chetty.
Reference: Gut
DOI: 10.1136/gutjnl-2019-318217
Year: 2020
Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
Authors: Kyaw L. Aung, Sandra E. Fischer, Robert E. Denroche, Gun-Ho Jang, Anna Dodd, Sean Creighton, Bernadette Southwood, Sheng-Ben Liang, Dianne Chadwick, Amy Zhang, Grainne M. O'Kane, Hamzeh Albaba, Shari Moura, Robert C. Grant, Jessica K. Miller, Faridah Mbabaali, Danielle Pasternack, Ilinca M. Lungu, John M.S. Bartlett, Sangeet Ghai, Mathieu Lemire, Spring Holter, Ashton A. Connor, Richard A. Moffitt, Jen Jen Yeh, Lee Timms, Paul M. Krzyzanowski, Neesha Dhani, David Hedley, Faiyaz Notta, Julie M. Wilson, Malcolm J. Moore, Steven Gallinger, Jennifer J. Knox.
Reference: Clinical Cancer Research
DOI:10.1158/1078-0432.CCR-17-2994
Year: 2018
